ORGANIC GERMANIUM / GERMANIUM SESQUIOXIDE — SCIENCE WEBSITE
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Table of Contents: 
Analytical •AntimutagenicAntioxidant •Antiviral •Arthritis •Atherosclerosis •Bioavailability •CancerCataracts  •Cervix •DNA Repair •Fibrosis •Free Radical ScavengingHazards •Heart •History •Immune SystemKidneysInflammation •Liver •Osteoporosis •Pain Management Pharmacology •Reviews •Safety •Uterus

Free Radical Scavenging
Studies on the hydroxyl free radical-scavenging effect of combined selenium and germanium.  Wei Sheng Yan Jiu. 2001 Jul;30(4):208-10.

Wu Z, Chen X, Yang K, Xia T.

Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

The effect of selenium, carboxyethyl-germanium sesquioxide (Ge-132) and the combination of selenium and Ge-132 on the production of hydroxyl free radical in liver microsomes of rats treated with Fe2SO4-NADPH system was studied with electron spin resonance technique (ESR). The results showed that the production of hydroxyl free radical was decreased significantly by adding selenium, Ge-132 and combined selenium and Ge-132, indicating a direct scavenging effect on hydroxyl free radical. It was also observed a enhanced scavenging effect at the low concentration of combined selenium and Ge-132.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=
12561515&query_hl=2&itool=pubmed_DocSum

Free Radical Scavenging
Protective effect of carboxyethylgermanium sesquioxide (Ge-132) on superoxide generation by 60Co-irradiated leukocytes. Biotherapy. 1991;3(3):273-9.

Pronai L, Arimori S.

Second Department of Internal Medicine, Semmelweis University Medical School, Budapest, Hungary.

The carboxyethylgermanium sesquioxide, Ge-132, is an organogermanium compound which has been shown to modulate leukocyte functions. In this study, we examined the effect of Ge-132 on the generation of superoxide radicals (O2-) either from leukocytes or in cell-free system, employing the highly sensitive 2-methyl-6-[p-methoxy-phenyl]-3,7-dihydroimidazo[1,2-alpha]pyra zin-3-one (MCLA)-dependent chemiluminescence method and the specific electron spin resonance/spin trapping method, respectively. In addition, the in vitro protective effect of Ge-132 on the leukocytes irradiated with 60Co was studied. The incubation with Ge-132 resulted in an increase in basal O2- release of intact leukocytes, but had no effect on O2- generation from leukocytes stimulated with phorbol myristate acetate (PMA). Irradiation with 60Co decreased the O2- generation from leukocytes in a dose-dependent manner. Ge-132 had no effect on basal O2- release from 60Co-irradiated leukocytes, but it prevented the decrease in PMA-stimulated O2- generation by irradiated leukocytes. Ge-132 itself had no superoxide scavenging activity in cell-free system. On the other hand, higher concentrations of Ge-132 had decreasing effects on both basal O2- release and PMA-stimulated O2- generation from leukocytes, but they did not affect leukocyte viability. Above results indicate that 1) Ge-132 can stimulate the basal O2- release from leukocytes, 2) Ge-132 can prevent the decrease of O2- generation by 60Co-irradiated leukocytes, 3) in higher concentrations, Ge-132 may have a membrane stabilizing effect.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=
1649617&query_hl=48&itool=pubmed_DocSum

Free Radical Scavenging, Antioxidant
Effects of selenium and germanium on lipid peroxidation in rats fed with low-selenium grain.  Zhonghua Yu Fang Yi Xue Za Zhi. 1996 Mar;30(2):88-90.

Xie W, Chen X, Yang K.

Department of Environmental Health Tongji Medical University, Wuhan.

Rats were fed with grain produced in the area prevalent of Keshan disease for 12 weeks, by adding certain amount of sodium selenite (Na2SeO3) and carboxylethylgermanium (Ge-132) to study the combined effects of selenium and germanium on lipid peroxidation and metabolism of free radicals in their bodies. Results showed selenium and germanium added to the grain could reduce the content of free radicals in rats' liver and kidney tissues, and that of lipid peroxide in their heart, liver and kidney, and increase the activities of glutathione peroxidase (GSH-Px) in their blood, in a synergic way. PMID: 8758855 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=
8758855&query_hl=8&itool=pubmed_DocSum

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