The Authoritative Germanium Sesquioxide Resource

Table of Contents: 
Analytical •AntimutagenicAntioxidant •Antiviral •Arthritis •Atherosclerosis •Bioavailability •CancerCataracts  •Cervix •DNA Repair •Fibrosis •Free Radical ScavengingHazards •Heart •History •Immune SystemKidneysInflammation •Liver •Osteoporosis •Pain Management Pharmacology •Reviews •Safety •Uterus

Antioxidant, Liver
Protective role of germanium-132 against paraquat-induced oxidative stress in the livers of senescence-accelerated mice.
J Toxicol Environ Health A. 1999 Nov 12;58(5):289-97.

Yang MK, Kim YG.

Department of Biological Science, College of Natural Sciences, Chosun University, Dong-ku, Kwangju, Korea.

The effects of the synthetic antioxidant germanium (Ge-132) were studied on liver oxidant damage induced by paraquat (PQ) in senescence-accelerated mice (SAM). PQ administered intravenously to SAM-P/8 (susceptible) or SAM-R/1 (resistant) mice increased liver DNA strand breakage and malondialdehyde (MDA) levels, indicators of oxidant damage. Ge-132 effectively blocked the PQ-induced effects on liver DNA strand breaks and MDA levels. In addition, Ge-132 significantly elevated the activities of hepatic superoxide dismutase (SOD) and catalase following PQ pretreatment. Histopathologically, Ge-132 inhibited PQ-induced hepatic mitochondrial injury in both strains, but more effectively in the susceptible strain. Data suggest that Ge-132 may be useful as an antioxidant in view of its ability to prevent PQ-induced hepatic oxidant injury.

Free Radical Scavenging, Antioxidant
Effects of selenium and germanium on lipid peroxidation in rats fed with low-selenium grain.  Zhonghua Yu Fang Yi Xue Za Zhi. 1996 Mar;30(2):88-90.

Xie W, Chen X, Yang K.

Department of Environmental Health Tongji Medical University, Wuhan.

Rats were fed with grain produced in the area prevalent of Keshan disease for 12 weeks, by adding certain amount of sodium selenite (Na2SeO3) and carboxylethylgermanium (Ge-132) to study the combined effects of selenium and germanium on lipid peroxidation and metabolism of free radicals in their bodies. Results showed selenium and germanium added to the grain could reduce the content of free radicals in rats' liver and kidney tissues, and that of lipid peroxide in their heart, liver and kidney, and increase the activities of glutathione peroxidase (GSH-Px) in their blood, in a synergic way. PMID: 8758855 [PubMed - indexed for MEDLINE]

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